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Melasma Treatment Guide and Product Recommendations

Client Prep & Skin Assessment
Evaluate melasma type (epidermal, dermal, vascular), sensitivity, and contraindications; document baseline photos.
Cleanse with Zena Cleansing Gel (Mild exfoliating, anti‑inflammatory, antioxidant) and tone with Zena Skin Toner to reduce inflammation and preps the skin as an anti‑bacterial degreaser.

Phase 1 Calm, Repair and Reduce Inflammation, Week 1-2
Client Prep & Skin Assessment

Use shallow depth (0.25–0.5 mm) to avoid inflammation. Avoid inflammation — deeper needling worsens pigment
Apply Zena Redless or Hyalchol Cocktail to calm redness, strengthen vessels, and reduce vascular melasma signaling.

Phase 2 Tyrosinase Suppression and Melanin Control, Week 3-6
Microneedle using Zena Pro Whitening+ to suppress tyrosinase and reduce melanin production.
Apply MC Cosmetics Exosome TRX for pigment suppression or Exosome PDRN for regeneration; infuse via dermapen at 0.25–0.5 mm.

Phase 3 Vascular Melasma Control (VEGF Pathway)

Vascular Strengthening using Zena Hyalchol Cocktail Strengthens blood vessels, reduces swelling, improves microcirculation

Anti‑Redness / Vascular Drainage  using Zena Redless Strong anti‑inflammatory + vascular sealing

Vascular Pigment Control using MC Cosmetics Exosome TRX 1500UI Tranexamic Acid + Niacinamide — reduces pigmentation + vascular redness


Phase 4 Controlled Exfoliation (If Indicated)

Melasma requires gentle, controlled exfoliation — not aggressive peels. Perform a gentle peel such as Zena Mandelic 15% or MAZ 20 only when skin is stable and inflammation is controlled.

Option A — Zena Mandelic 15% (Sensitive Melasma)
Ideal for melasma, photoaging, irregular pigmentation

Option B — Zena MAZ 20 (Mandelic + Azelaic)
Perfect for sensitive, rosacea‑linked melasma

Option C — Zena Lactic 30% (Dry, dehydrated melasma)
Gentle, hydrating, brightening

Option D — Zena Natural Pro‑Retinol Peel
Non‑acid peel, reduces hyperpigmentation, anti‑inflammatory





LED Therapy & Recovery - Use after peels, microneedling or Mesotherapy procedures


Use yellow LED for vascular melasma or red LED for inflammation; finish with Zena HYAL HMW/LMW for hydration and Zena Sunblock SPF 50. Post‑procedure protection, prevents melasma recurrence

Homecare Recommendations:

Option 1: Zena Cosmetics
Zena Exolume Face Serum - exosome driven absorption. cellular vitality boost.

Zena Exolume Face Cream - 


Option 2: Melanin Control
Melanin Control Tyrosinase Inhibitor Skin Brightening Cream - Contains tyrosinase‑blocking actives. Ideal for daily use once inflammation is controlled. Supports fading of epidermal pigment.

Melanin Control Advanced Barrier Restore Cream - Ceramide‑rich barrier repair. Reduces chronic inflammation. Essential before introducing brighteners

Melanin Control Hyaluronic Acid 1% Hydrating Serum - Hydration reduces inflammatory signaling. Supports skin resilience during treatment.


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